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Mycobacterium tuberculosis Phagosome Maturation Arrest: Selective Targeting of PI3P‐Dependent Membrane Trafficking
Author(s) -
Vergne Isabelle,
Chua Jennifer,
Deretic Vojo
Publication year - 2003
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1034/j.1600-0854.2003.00120.x
Subject(s) - phagolysosome , phagosome , biology , microbiology and biotechnology , mycobacterium tuberculosis , biogenesis , tuberculosis , organelle biogenesis , intracellular , genetics , gene , medicine , pathology
The ability of Mycobacterium tuberculosis to enter host macrophages, and reside in a phagosome, which does not mature into a phagolysosome, is central to the spread of tuberculosis and the associated pandemic involving billions of people worldwide. Tuberculosis can be viewed as a disease with a significant intracellular trafficking and organellar biogenesis component. Current understanding of the block in M. tuberculosis phagosome maturation also sheds light on fundamental aspects of phagolysosome biogenesis. The maturation block involves interference with the recruitment and function of rabs, rab effectors (phosphatidylinositol 3‐kinases and tethering molecules such as EEA1), SNAREs (Syntaxin 6 and cellubrevin) and Ca 2+ /calmodulin signaling. M. tuberculosis analogs of mammalian phosphatidylinositols interfere with these systems and associated processes.