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Endocytosis Via Caveolae
Author(s) -
Pelkmans Lucas,
Helenius Ari
Publication year - 2002
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1034/j.1600-0854.2002.30501.x
Subject(s) - internalization , endocytosis , caveolae , transcytosis , biology , microbiology and biotechnology , cholera toxin , autocrine signalling , receptor mediated endocytosis , clathrin , endosome , signal transduction , intracellular , cell , biochemistry , receptor
Caveolae are flask‐shaped invaginations present in the plasma membrane of many cell types. They have long been implicated in endocytosis, transcytosis, and cell signaling. Recent work has confirmed that caveolae are directly involved in the internalization of membrane components (glycosphingolipids and glycosylphosphatidylinositol‐anchored proteins), extracellular ligands (folic acid, albumin, autocrine motility factor), bacterial toxins (cholera toxin, tetanus toxin), and several nonenveloped viruses (Simian virus 40, Polyoma virus). Unlike clathrin‐mediated endocytosis, internalization through caveolae is a triggered event that involves complex signaling. The mechanism of internalization and the subsequent intracellular pathways that the internalized substances take are starting to emerge.