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An Overview of C. Elegans Trafficking Mutants
Author(s) -
Nurrish Stephen J.
Publication year - 2002
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1034/j.1600-0854.2002.30102.x
Subject(s) - caenorhabditis elegans , biology , mutant , genetic screen , microbiology and biotechnology , caenorhabditis , model organism , gene , genetics , computational biology
It is almost 40 years since Sydney Brenner introduced Caenorhabditis elegans as a model genetic system. During that time mutants with defects in intracellular trafficking have been identified in a diverse range of screens for abnormalities. This should, of course, come as no surprise as it is hard to imagine any biological process in which the regulated movement of vesicles within the cells is not critical at some step. Almost all of these genes have mammalian homologs, and yet the role of many of these homologs has not been investigated. Perhaps the protein that regulates your favorite trafficking step has already been identified in C. elegans ? Here I provide a brief overview of those trafficking mutants identified in C. elegans and where you can read more about them.