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Neurotoxic Traffic: Uncovering the Mechanics of Amyloid Production in Alzheimer's Disease
Author(s) -
Huse Jason T.,
Doms Robert W.
Publication year - 2001
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1034/j.1600-0854.2001.020201.x
Subject(s) - proteases , biology , amyloid precursor protein , alpha secretase , neuroscience , intracellular , p3 peptide , amyloid (mycology) , microbiology and biotechnology , neurodegeneration , biochemistry of alzheimer's disease , disease , alzheimer's disease , presenilin , amyloid β , computational biology , biochemistry , pathology , enzyme , medicine , botany
Alzheimer's disease (AD) is thought by many to result from the accumulation of the neurotoxic amyloid‐β (Aβ) peptide in brain parenchyma. The process by which Aβ is proteolytically derived from the larger amyloid precursor protein (APP) has been the focus of much attention in the AD research field over the past decade. Recently, several of the proteins directly involved in the generation of Aβ have been identified and characterized providing a number of viable therapeutic targets for the treatment of AD. However, the cellular mechanisms by which these proteins interact in the proteolytic processing of APP have not been well defined, nor are they readily apparent when one considers what is known about the intracellular localization and trafficking of the various participants. This article will review the underlying cell biology of Aβ production and discuss the mechanistic options for APP processing given the current knowledge of the proteases involved.