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The Protein Import Machinery of the Mitochondrial Membranes
Author(s) -
Rassow Joachim,
Pfanner Nikolaus
Publication year - 2000
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1034/j.1600-0854.2000.010603.x
Subject(s) - intermembrane space , biology , mitochondrial intermembrane space , protein targeting , translocase of the inner membrane , microbiology and biotechnology , mitochondrial membrane transport protein , translocase of the outer membrane , transport protein , mitochondrion , inner mitochondrial membrane , mitochondrial carrier , membrane , membrane protein , biochemistry , bacterial outer membrane , gene , escherichia coli
Mitochondria are surrounded by two membranes that contain independent and non‐related protein transport machineries. Remarkable progress was recently achieved in elucidating the structure of the outer membrane import channel and in the identification of new components involved in protein traffic across the intermembrane space and the inner membrane. Traditional concepts of protein targeting and sorting had to be revised. Here we briefly summarize the data on the mitochondrial protein import system with particular emphasis on new developments and perspectives.