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Garrotes, Springs, Ratchets, and Whips: Putting Dynamin Models to the Test
Author(s) -
Sever Sanja,
Damke Hanna,
Schmid Sandra L.
Publication year - 2000
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1034/j.1600-0854.2000.010503.x
Subject(s) - dynamin , gtpase , endocytosis , biology , microbiology and biotechnology , clathrin , biophysics , biochemistry , receptor
The GTPase dynamin is essential for clathrin‐mediated endocytosis. Numerous new and exciting discoveries regarding dynamin function in vivo and in vitro have led to various models in which dynamin functions directly in membrane fission and the release of clathrin‐coated vesicles from the plasma membrane. This would make dynamin unique among GTPases in its ability to act as a mechanochemical enzyme. Here we review the various models and their supporting data. We then discuss new findings that raise doubts as to whether dynamin breaks the paradigm that governs regulatory GTPases.