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Antigen Traffic Pathways in Dendritic Cells
Author(s) -
Watts Colin,
Amigorena Sebastian
Publication year - 2000
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1034/j.1600-0854.2000.010404.x
Subject(s) - biology , immune system , microbiology and biotechnology , endocytic cycle , dendritic cell , antigen presentation , antigen presenting cell , antigen , major histocompatibility complex , cell , t cell , immunology , endocytosis , genetics
Dendritic cells (DC) are now believed to be the principal initiators of T cell‐mediated immune responses. Their location in body tissues, migratory behaviour in response to inflammatory stimuli, endocytic properties, expression of MHC molecules and key T cell stimulatory molecules and many other attributes place these remarkable cells in a unique and influential position in the immune system. Progress in DC culture methods has recently allowed in‐depth studies on the cell biological features that enable them to fulfil their crucial role in the immune response.