Open AccessSplit face study on the cutaneous tensile effect of 2‐dimethylaminoethanol (deanol) gel
Author(s) -
Uhoda Isabelle,
Faska Najat,
Robert Caroline,
Cauwenbergh Geert,
Piérard Gérald. E.
Publication year - 2002
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1034/j.1600-0846.2002.10295.x
Subject(s) - distension , shear (geology) , suction , anisotropy , materials science , wave velocity , composite material , mathematics , biomedical engineering , medicine , surgery , optics , physics , thermodynamics
Background/aims: Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2‐phase randomized double‐blind split face study was designed to compare the effect of a gel containing 3% 2‐dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE. Methods: In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured. Results: Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness. Conclusion: The DMAE formulation under investigation increased skin firmness.