Open AccessIs vascular reactivity in skin predictable?
Author(s) -
Lindén Maria,
Andersson Thomas,
Wårdell Karin,
Anderson Chris
Publication year - 2000
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1034/j.1600-0846.2000.006001027.x
Subject(s) - provocation test , microdialysis , histamine , medicine , anesthesia , catheter , perfusion , surgery , pharmacology , pathology , alternative medicine , central nervous system
Background/aims: Cutaneous microdialysis can be used to follow the pharmacology and metabolism of an inflammatory reaction. It is assumed that an equilibration period compensates for the trauma of catheter insertion. Methods: In the present paper, the vascular reactivity of the skin to histamine was tested using assessment by laser Doppler perfusion imaging. In a group of six subjects, the provocation was preceded by insertion of a microdialysis catheter. In a second control group, histamine provocation alone was performed (six subjects). Results: The vascular response to histamine was greater in the microdialysis catheter group than the control group. The histamine provocation caused a greater response than catheter insertion. Further, there was a correlation between the response to catheter insertion and the histamine provocation. Conclusion: It appears that the insertion and/or presence of a microdialysis catheter increases vascular reactivity to subsequent provocation. The response to catheter insertion may predict skin reactivity in general in the individual subject.