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Release of muscle proteins after downhill running in male and female subjects
Author(s) -
Sorichter S.,
Mair J.,
Koller A.,
Calzolari C.,
Huonker M.,
Pau B.,
Puschendorf B.
Publication year - 2001
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1034/j.1600-0838.2001.011001028.x
Subject(s) - medicine , endocrinology , myoglobin , creatine kinase , skeletal muscle , myosin , basal (medicine) , heart rate , troponin t , biology , blood pressure , biochemistry , myocardial infarction , insulin
The release of muscle proteins after downhill running, which mainly includes eccentric muscle action, was compared in females (F; n =9) and males (M; n =9). They performed 20 min of downhill treadmill running with 16% decline with a target heart rate of 70% of the individual VO 2peak , which was determined two weeks before. Blood samples were drawn before, 6 and 24 h after exercise to measure plasma levels of skeletal troponin I (sTnI), myosin heavy chain fragments (MHC), creatine kinase (CK), and myoglobin (Mb). Baseline levels before exercise were significantly higher in males compared to females for the cytoplasmic proteins CK and Mb, but the difference for MHC and sTnI was not significant. Both groups displayed marked and significant early (6 h) increases ( P <0.05) for sTnI (median: F: 8.2 μg/L; M: 22.0 μg/L), Mb (median: F: 86.8 μg/L; M: 407 μg/L), and CK (median: F: 162 U/L; M: 339 U/L). A significant ( P <0.05) but delayed (24 h) increase was found for MHC (median: F: 482 μU/L; M: 651 μU/L). The absolute values for all four parameters were significantly ( P <0.05) higher in males compared to females; however, no difference was found for the relative increases and the time course of all parameters between females and males. We conclude 1) that there were no significant differences in the basal concentrations of predominantly bound proteins, and 2) that there were no differences in the relative muscle protein release between females and males before and after one bout of high‐intensive eccentric exercise. The higher plasma concentrations of all measured muscle proteins in males are probably caused by the higher muscle mass compared to females.