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Melatonin prevents free radical formation due to the interaction between β ‐amyloid peptides and metal ions [Al(III), Zn(II), Cu(II), Mn(II), Fe(II)]
Author(s) -
Zatta Paolo,
Tog Giuseppe,
Carampin Paolo
Publication year - 2003
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1034/j.1600-079x.2003.00058.x
Subject(s) - melatonin , chemistry , peptide , amyloid (mycology) , metal ions in aqueous solution , oxidative stress , reactive oxygen species , biophysics , metal , amyloid beta , biochemistry , endocrinology , inorganic chemistry , biology , organic chemistry
Alzheimer's disease, among other pathological features, is characterized by an over‐accumulation of amyloid‐ β peptide, metal ions, and oxidative stress proteins in the brain. Amyloid‐ β aggregated peptides with bound metal ions may initiate free radical generation with consequent protein and lipid oxidation, reactive oxygen species formation and eventually neuronal death. Melatonin is able to dramatically reduce the free radical formation which follows the interaction between transition metal ions and amyloid‐ β . This paper reports the scavenging effect of melatonin of reactants generated by amyloid peptides in combination with some metal ions.