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Topical 5‐aminolaevulinic acid photodynamic therapy for cutaneous lesions: outcome and comparison of light sources
Author(s) -
Clark C.,
Bryden A.,
Dawe R.,
Moseley H.,
Ferguson J.,
Ibbotson S. H.
Publication year - 2003
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1034/j.1600-0781.2003.00024.x
Subject(s) - photodynamic therapy , actinic keratosis , dermatology , medicine , bowen's disease , actinic keratoses , keratosis , intense pulsed light , basal cell carcinoma , adverse effect , basal cell , pathology , chemistry , organic chemistry
Background: Topical 5‐aminolaevulinic acid (ALA) photodynamic therapy (PDT) is increasingly used for superficial non‐melanoma skin cancers and their precursors. Methods: We report our 3‐year experience of topical ALA‐PDT, with a preliminary comparison of the effects of broadband and laser light sources. Results: We performed 688 treatments on 483 lesions in 207 patients. Complete clearance was achieved in 222/239 lesions of Bowen's disease (BD), superfi‐cial basal cell carcinoma (sBCC) and actinic keratosis (AK) (93%) – 117/129 BD (91%), 84/87 sBCC (97%) and 21/23 AK (91%), with a median follow up of 48 weeks. Broadband and laser light sources were of similar efficacy. Recurrences have occurred in 10.3% BD, 4.8% sBCC and 4.8% AK. Adverse effects from PDT were uncommon but included pig‐mentary change (2%) and minor scarring (2%). How‐ever, severe pain was experienced in 16–21% of treatments using the high‐output broadband and laser sources, but in only 2% with the low‐output xenon arc source. Conclusion: Topical ALA‐PDT is effective for BD, sBCC and AK and has been an invaluable addition to our dermatology service. Efficacy is similar for broadband and laser light sources, although treatment at higher surface irradiance may be painful, and excellent cosmetic results can be achieved.