Premium
001 UVA‐1 for the treatment of chronic hand dermatitis
Author(s) -
Bergamo B.,
Elmets C.
Publication year - 2002
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1034/j.1600-0781.2002.180208_1.x
Subject(s) - medicine , dermatology , atopic dermatitis
UVA‐1 has distinct immunological effects which has allowed it to be useful for a number of cutaneous diseases that have been relatively resistant to other treatment modalities. These include urticaria pigmentosa, morphea/scleroderma and T‐cell mediated diseases such as atopic dermatitis and cutaneous T‐cell lymphoma. Since chronic hand dermatitis is also mediated by T‐cells, we hypothesized that UVA‐ 1 would be an effective treatment for that disease as well. Five subjects with recalcitrant hand dermatitis caused by dyshidrosis and/or chronic irritancy were treated with a medium dose regimen of UVA‐ 1. This consisted of 15 treatments of 60 J/cm 2 UVA 1 over 3 weeks. Subjects received a total of 900 J/cm 2 . A clinical scoring parameter, Dyshidrotic Area and Seventy Index Score (DASI), was administered to subjects prior to and following the UVA‐ 1 treatment course. Clinical photographs were also taken. All subjects showed improvement in hand dermatitis as demonstrated by clinical photographs and the DASI score (13 ± 5.35 before treatment; 6.3 ± 4.50 after treatment). UVA‐ 1 is an effective and rapid acting treatment for chronic hand dermatitis.