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Evaluation of the inhibitory activity of topical indomethacin, betamethasone valerate and emollients on UVL‐induced inflammation by means of non‐invasive measurements of the skin elasticity
Author(s) -
Dobrev Hristo
Publication year - 2001
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1034/j.1600-0781.2001.170408.x
Subject(s) - emulsion , erythema , chemistry , dermatology , pharmacology , medicine , biochemistry
Background/Aim: Topical indomethacin has been reported to inhibit ultraviolet light‐induced erythema. The objective of this study was to verify this assertion and to compare indomethacin 10% ointment to betamethasone valerate 0.1% ointment, water‐in‐oil emulsion and oil‐in‐water emulsion by means of non‐invasive skin elasticity measurements. Methods: Products were applied on the back skin 60 min and 5 min before and 5 min after UVL irradiation. Untreated test sites served as controls. Clinical evaluation, measurements of epidermal hydration (Corneometer) and mechanical properties of the skin (Cutometer) were made 1 h before and 24 h after exposure. Results: Test areas treated with indomethacin 60 min and 5 min before irradiation showed the significantly lowest visual erythema scores and no significant changes in skin mechanical parameters. At all other test sites, a significant decrease in elasticity parameters (Ue, Ur, Ua/Uf, Ur/Uf) and an increase in viscoelasticity parameters (Uv, Uv/Ue) of the skin were observed. No significant changes of epidermal hydration were found at any of the test sites. Conclusion: The inhibitory action of topical indomethacin on UVL‐induced inflammation is superior to betamethasone valerate and emollients. Non‐invasive measurement of skin elasticity could be used as a supplementary tool for objective evaluation and comparison of the photoprotective activity of different topical agents.