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The pathophysiology of photosensitivity in lupus erythematosus
Author(s) -
Orteu Catherine H.,
Sontheimer Richard D.,
Dutz Jan P.
Publication year - 2001
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1034/j.1600-0781.2001.170301.x
Subject(s) - photosensitivity , pathogenesis , systemic lupus erythematosus , lupus erythematosus , pathophysiology , abnormality , medicine , immunology , dermatology , disease , pathology , psychiatry , physics , quantum mechanics , antibody
The strong association between photosensitivity and lupus erythematosus has led to the suggestion that abnormal photoreactivity participates in the pathogenesis of cutaneous lesions. In this review we discuss the evidence for abnormal cutaneous reactivity to sunlight in lupus and speculate on the cellular, molecular and genetic factors that may underlie this abnormality.