Open AccessEffect of Acute and Chronic Lead Exposure on Apomorphine‐Induced Sniffing in Rats
Author(s) -
FazliTabaei Soheila,
Fahim Mohammad,
Zarrindast MohammadReza
Publication year - 2003
Publication title -
pharmacology & toxicology
Language(s) - English
Resource type - Journals
eISSN - 1600-0773
pISSN - 0901-9928
DOI - 10.1034/j.1600-0773.2003.920205.x
Subject(s) - apomorphine , sniffing , dopamine receptor , dopamine , agonist , dopaminergic , dopamine agonist , pharmacology , endocrinology , lead acetate , receptor , medicine , chemistry , toxicity , anatomy
Sniffing is a behaviour which can be induced by dopamine D 1/ D 2 receptor agonists. In order to test the effect of chronic lead exposure on dopamine receptor subtypes, we studied the effects of acute and chronic lead exposure on sniffing induced by apomorphine, a dopamine receptor agonist. Intraperitoneal injection of the dopaminergic receptor agonist, apomorphine (0.25–1 mg/kg), induced dose‐dependent the sniffing behaviour in rats. Acute administration of lead acetate (50, 100 and 200 mg/kg) decreased the apomorphine‐induced sniffing. Chronic lead (0.25%) exposure also decreased the apomophine response. Dopamine D 1 or D 2 receptor antagonists reduced the apomorphine effect. Lead exposure could not potentiate the blockade induced by the dopamine receptor antagonists. It is concluded that the response of lead is not mediated by alteration of dopamine receptors.