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Effect of periodontal treatment on the activity of chitinase in whole saliva of periodontitis patients
Author(s) -
Van Steijn G. J.,
Nieuw Amerongen A. V.,
Veerman E. C. I.,
Kasanmoentalib S.,
Overdijk B.
Publication year - 2002
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1034/j.1600-0765.2002.00330.x
Subject(s) - saliva , chitinase , periodontitis , enzyme , enzyme assay , bleeding on probing , chemistry , medicine , microbiology and biotechnology , biology , biochemistry
Human salivary chitinase could play a role in the defence against chitin‐containing oral pathogens. The activity levels of chitinase in the whole saliva of periodontitis patients were significantly higher than those in saliva from controls. Periodontal treatment for a period of 5–6 months resulted in a three‐ to fourfold decrease in this enzyme activity. The activity of β‐ N ‐acetylhexosaminidase, which is another enzyme that hydrolyses glycosidic linkages, also decreased as a result of treatment, although to a lesser extent. The decrease in chitinase activity upon treatment of the disease did not correlate with the decrease that was seen in clinical attachment loss and bleeding on probing, and only a weak correlation was observed with the changes in probing pocket depth and plaque index. No correlations were found between the above clinical parameters and the decrease in β‐ N ‐acetylhexosaminidase activity.