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Histometric evaluation of the effect of nicotine administration on periodontal breakdown: an in vivo study
Author(s) -
Nociti Francisco H.,
NogueiraFilho Getúlio R.,
Tramontina Vinícius A.,
Naval Machado Maria A.,
Barros Silvana P.,
Sallum Enilson A.,
Sallum Antonio Wilson
Publication year - 2001
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1034/j.1600-0765.2001.360603.x
Subject(s) - nicotine , saline , ligature , periodontitis , analysis of variance , medicine , intraperitoneal injection , molar , in vivo , dentistry , anesthesia , biology , microbiology and biotechnology
The present study investigated the effect of nicotine administration on periodontal breakdown resulting from ligature‐induced periodontitis in rats. Twenty adult male Wistar rats were used. After anesthesia, a mandibular first molar was randomly assigned to receive a cotton ligature in the sulcular area while the contralateral tooth was left unligated. The animals were randomly assigned to one of the following treatments, of daily intraperitoneal injections: A – saline solution, B – 0.37 mg of nicotine/kg, C – 0.57 mg of nicotine/kg and D – 0.73 mg of nicotine/kg. Thirty days later, the animals were sacrificed and the specimens routinely processed for serial decalcified sections. Statistical analysis (ANOVA) revealed greater bone loss ( p <0.05) in the ligated teeth of animals which received nicotine (groups B/C/D) than in the ligated teeth of animals which received saline solution (group A). In addition, a dose‐dependent response was observed among the nicotine groups. A negative effect of nicotine was observed in the unligated teeth of the experimental groups ( p <0.05). Therefore, daily administration of nicotine enhanced, in a dose‐dependent manner, the effects of local factors in producing periodontal breakdown. Furthermore, the nicotine seemed to have a direct deleterious effect on the periodontal tissues.