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Prevalence of periodontal pathogens in localized and generalized forms of early‐onset periodontitis
Author(s) -
Mullally Brian H.,
Dace Barry,
Shelburne Charles E.,
Wolff Larry F.,
Coulter Wilson A.
Publication year - 2000
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1034/j.1600-0765.2000.035004232.x
Subject(s) - eikenella corrodens , prevotella intermedia , treponema denticola , actinobacillus , periodontitis , bacteroides , microbiology and biotechnology , medicine , porphyromonas gingivalis , biology , bacteria , genetics
The primary objectives of this study were to investigate the prevalence of 8 putative periodontal pathogens in subjects with early‐onset periodontitis (EOP) and to evaluate the microbial differences between localized and generalized forms of this periodontal disease condition. Thirty‐one females and 11 males with a mean age of 30.3 (s.d. 4.0) years were examined. Seventeen subjects had generalized (GEOP) and 25 had localized early‐onset periodontitis (LEOP). Subgingival plaque samples were assayed using PCR which provided subject prevalence data for the pathogens; Bacteroides forsythus 78.6%, Treponema denticola 88.1%, Actinobacillus actinomycetemcomitans 19.0%, Porphyromonas gingivalis 16.7%, Prevotella intermedia 40.4%, Prevotella nigrescens 61.9%, Eikenella corrodens 42.3% and Campylobacter rectus 92.8%. Only 3 healthy sites harbored one or more of these periodontal pathogens. Seven of the 8 subjects positive for A. actinomycetemcomitans had LEOP. P. intermedia was present in 58.8% of GEOP compared with 28% of LEOP subjects ( p =0.046). At 82.4% of GEOP sites P. nigrescens was present while this bacteria was detected at 52% of LEOP ( p =0.044). P. gingivalis was isolated from 22.6% of females but no male subjects ( p =0.084). C. rectus was recovered from all female subjects compared to 72.7% of males ( p =0.014). A. actinomycetemcomitans (37.5%) and C. rectus (86.5%) were more frequently identified in non‐smokers compared to 7.6% and 68.8% of smokers, respectively ( p <0.05). Microbial associations coincided with the clinical division of the cases into LEOP and GEOP in 83% of the subjects.