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Effects of local injection of prilocaine–felypressin on the myocardial oxygen balance in dogs
Author(s) -
Miyachi Kenji,
Ichinohe Tatsuya,
Kaneko Yuzuru
Publication year - 2003
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1034/j.1600-0722.2003.00050.x
Subject(s) - prilocaine , anesthesia , medicine , blood pressure , pulmonary wedge pressure , chloralose , heart rate , cardiac output , hemodynamics , cardiology , local anesthetic
The authors investigated the effects of felypressin (Fely), a non‐adrenergic vasoconstrictor, used together with prilocaine on myocardial oxygen balance. Six open‐chest dogs were studied under urethane and α‐chloralose anesthesia. Systolic arterial pressure, diastolic arterial pressure, mean pulmonary arterial pressure and pulmonary capillary wedge pressure, heart rate, coronary blood flow (CBF), internal and external myocardial oxygen tension (int‐ or ext‐PmO 2 ), and cardiac output were observed. Three doses of Citanest–Octapressin, which contains 3% prilocaine and 0.03 IU ml −1 Fely (Pri‐Fely) – 0.09, 0.18, and 0.3 ml kg −1 – were injected into the tongue. Observations were performed up to 60 min after the injection. The CBF and int‐PmO 2 was reduced following the injection of each of the three doses of Pri‐Fely. There were negative correlations between the Pri‐Fely dose per body weight and the maximum reductions in CBF ( r = 0.52, P > 0.05), in int‐PmO 2 ( r = 0.78, P > 0.05), and in ext‐PmO 2 ( r = 0.55, P > 0.05), respectively. These results suggest that an administration of Fely at doses more than 2.7–5.4 mIU kg −1 (3–6 cartridges of Pri‐Fely) may induce an imbalance between the oxygen supply and demand in myocardial tissues of patients with cardiovascular diseases.