Premium
Effect of ethanol on lipid metabolism and epithelial permeability barrier of skin and oral mucosa in the rat
Author(s) -
Squier Christopher A.,
Kremer Mary J.,
Wertz Philip W.
Publication year - 2003
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1034/j.1600-0714.2003.00198.x
Subject(s) - lipid metabolism , ethanol , chemistry , endocrinology , medicine , metabolism , epithelium , permeability (electromagnetism) , carcinogen , biochemistry , biology , pathology , membrane
Background: Ethanol consumption induces changes in lipid metabolism. This might be reflected locally as an alteration in the epithelial lipid barrier. Methods: Rats were fed with an isocaloric liquid diet with, or without, ethanol (6.7%) and were sacrificed at 60 or 120 days. Plasma and liver triglycerides, γ‐glutamyl‐transferase (GGTP) levels, and permeability ( K p ) of skin and buccal mucosa to tritiated water and the tobacco carcinogen, nitrosonornicotine, were determined. Results: Significant elevation of GGTP at 120 days and triglycerides at both 60 and 120 days was observed for rats fed with ethanol diet. For this diet, K p values to both penetrants increased significantly for skin in rats after 120 days compared to all other groups. Conclusion: The parallel between changes in lipid metabolism and permeability suggests that one effect of ingested alcohol is to alter the lipid‐containing permeability barrier of stratified squamous epithelium.