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Salivary gland tumours: immunoexpression of integrins β1, β3 and β4
Author(s) -
Loducca S. V. L.,
Mantesso A.,
Kapas S.,
Williams D. M.,
Araújo N. S.,
Araújo V. C.
Publication year - 2003
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1034/j.1600-0714.2003.00114.x
Subject(s) - integrin , adenoid cystic carcinoma , pathology , acinic cell carcinoma , immunohistochemistry , salivary gland , biology , carcinoma , adenocarcinoma , cell , medicine , cancer , mucoepidermoid carcinoma , genetics
Background: Integrins, heterodimeric transmembranic adhesion molecules composed of α and β subunits, have been implicated in normal and neoplastic biological processes. We investigated the patterns of expression of integrins subunits β1, β3 and β4 in neoplasms derived from the terminal segment of salivary glands in order to understand their expression patterns in the different structures of these tumours. Methods: Immunohistochemistry using ‘catalized signal amplification’ (CSA) detection system was applied to paraffin‐embedded specimens of polymorphous low‐grade adenocarcinoma, adenoid cystic carcinoma and acinic cell carcinoma. Normal salivary glands were used as controls. Results: Immunoexpression of integrins showed that neoplastic structures of the tumours studied tend to mimic the patterns seen in the normal structures of salivary glands from which they are derived. Anaplastic cells were negative for all integrins. Conclusions: This study revealed detailed topography of integrins in malignant tumours derived from intercalated acinar segment of salivary gland and this might be useful in the diagnosis of these lesions, especially of fine‐needle aspiration (FNA) products or small specimens derived form incisional biopsies.