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Expression of vascular endothelial growth factor in salivary gland carcinomas and its relation to p53, Ki‐67 and prognosis
Author(s) -
Lim Ji J.,
Kang Sungmin,
Lee Mi R.,
Pai Hyun K.,
Yoon Hye J.,
Lee Jae I.,
Hong Sam P.,
Lim Chang Y.
Publication year - 2003
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1034/j.1600-0714.2003.00073.x-i1
Subject(s) - perineural invasion , salivary gland , vascular endothelial growth factor , immunohistochemistry , pathology , medicine , angiogenesis , stage (stratigraphy) , carcinoma , univariate analysis , metastasis , oncology , cancer , multivariate analysis , vegf receptors , biology , paleontology
Background: Vascular endothelial growth factor (VEGF) has been demonstrated to play an important role in tumor angiogenesis and to influence prognosis in many cancers. But, its significance in salivary gland carcinomas has not been elucidated. The authors investigated the association between VEGF expression and clinicopathological factors, p53, and Ki‐67 to verify its validity as a prognostic factor. Methods: Surgical specimens from 45 patients with salivary gland carcinoma were examined for VEGF, p53, and Ki‐67 expression by immunohistochemical staining. The results were compared with the clinicopathological factors and the relationships were correlated. Results: VEGF expression was low in 14 cases, moderate in 15 cases, and high in 16 cases. It was significantly correlated with a variety of clinicopathological factors such as TNM stage, perineural and vascular invasion, and recurrence. VEGF showed significant association with the expression of p53 but not with that of Ki‐67. Univariate analysis showed that age, gender, lymph node metastasis, vascular invasion, p53, Ki‐67, and VEGF expression correlate with prognosis. Multivariate analysis demonstrated that VEGF is an independent prognostic factor for patients with salivary gland carcinomas. Conclusions: The results of this study suggest that VEGF expression is correlated with p53 expression and that it may have prognostic value in salivary gland carcinomas.