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Photodynamic therapy (PDT) using topically applied δ‐aminolevulinic acid (ALA) for the treatment of oral leukoplakia
Author(s) -
Sieroń Aleksander,
Adamek Mariusz,
KawczykKrupka Aleksandra,
Mazur Sebastian,
Ilewicz Leszek
Publication year - 2003
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1034/j.1600-0714.2003.00068.x
Subject(s) - photodynamic therapy , medicine , leukoplakia , oral cavity , buccal administration , oral leukoplakia , oral mucosa , dermatology , dentistry , buccal mucosa , surgery , pathology , cancer , chemistry , organic chemistry
Background: Photodynamic therapy (PDT) is a non‐invasive method for topical and selective treatment of pre‐malignant lesions of oral cavity. The aim of our study was to determine therapeutic response to PDT in patients with oral leukoplakia. Methods: Twelve patients participated in our study. Lesions affected a variety of intraoral sites. The most common location was buccal, gingival and mandibular mucosa. Patients were treated with topically applied 10% δ‐aminolevulinic acid (ALA) and light from an argon‐pumped dye laser. Irradiation was performed in several (6–8) sessions using light at 635 nm wavelength, delivering a total dose of 100 J/cm 2 per session. Results: A complete response was obtained in 10 out of 12 treated patients. One recurrence was observed during 6 months. Conclusion: Photodynamic therapy appears to be a feasible alternative to conventional therapy of pre‐malignant lesions of oral cavity.