Premium
Candida ‐induced stomatopyrosis and its relation to diabetes mellitus
Author(s) -
Vitkov Ljubomir,
Weitgasser Raimund,
Hannig Matthias,
Fuchs Karl,
Krautgartner Wolf Dietrich
Publication year - 2003
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1034/j.1600-0714.2003.00020.x
Subject(s) - medicine , diabetes mellitus , capsaicin , body mass index , population , stimulation , dermatology , gastroenterology , endocrinology , receptor , environmental health
Background: Glycaemic disorders and oral candidosis can be accompanied by burning mouth sensations. However, no clear relation between all three disorders is known. Methods: Seventy‐two native Upper‐Austrians with burning mouth sensations were examined and smears for Candida estimation were taken from the spots where the sensations were felt. All patients with previously unknown diabetes mellitus (DM) were subjected to an oral glucose tolerance test (OGTT). Use of glucocorticoid‐containing anti‐asthmatic sprays and the body mass index (BMI) were determined. Results: Of the examined non‐inhalers of sprays, 52% had increased candidal density. A correlation between that increase and type 2 DM was found. The burning sensations in all patients with increased candidal density subsided completely after anti‐mycotic therapy. Conclusion: The perception of burning sensations was hypothesised to occur via stimulation of the capsaicin (vanilloid) receptor by Candida metabolites. The Candida ‐induced stomatopyrosis should be regarded as a single symptom indicating (predisposition to or established) type 2 DM in non‐inhalers of the concerned population.