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Expression of the endothelial receptor tyrosine kinase Tie2 in lobular capillary hemangioma of the oral mucosa: an immunohistochemical study
Author(s) -
Sato Hirotaka,
Takeda Yasunori,
Satoh Masanobu
Publication year - 2002
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1034/j.1600-0714.2002.310708.x
Subject(s) - pathology , immunohistochemistry , capillary hemangioma , immunostaining , receptor tyrosine kinase , cd34 , biology , oral mucosa , angiopoietin receptor , tyrosine kinase , angiogenesis , hemangioma , medicine , receptor , kinase , cancer research , microbiology and biotechnology , biochemistry , stem cell
Background: Lobular capillary hemangioma (LCH) usually occurs in the skin or mucous membranes as a rapidly growing red nodule. LCH is one of the most common vascular lesions in the oral mucosa. Tie2 is a novel, human endothelial receptor tyrosine kinase which may play an important role in blood vessel formation. In this study, we investigated its immunohistochemical expression in LCH of the oral mucosa. Methods: Double immunostaining with anti‐CD34 and antiα smooth muscle actin (SMA) antibodies was performed to characterize the cellular expression of Tie2 in 15 cases of this condition. Results: We found Tie2 immunoreactivity in the ovoid cells only, which were frequently intermingled with αSMA‐positive cells, especially in the hypercellular portion of LCH. Conclusions: These results suggest that the expression of Tie2 in ovoid cells and the interaction between ovoid cells and αSMA‐positive cells play an important part in the development and progression of LCH.