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Ameloblastic fibrosarcoma of the mandible: report of two cases and review of the literature
Author(s) -
Bregni Roman Carlos,
Taylor Adalberto Mosqueda,
García Abelardo Meneses
Publication year - 2001
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1034/j.1600-0714.2001.300510.x
Subject(s) - medicine , lesion , fibrosarcoma , mandible (arthropod mouthpart) , odontogenic tumor , odontogenic , mandibular neoplasms , neoplasm , pathology , radiology , dentistry , maxilla , biology , botany , genus
Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumour. To date, 60 well‐documented cases have been published in the English‐language literature. Two additional cases located in the posterior region of the mandible are reported. The relevant clinicopathological features of these cases, as well as those previously reported are discussed. Approximately two‐thirds of AFS are malignant tumors de novo , with an average age of the affected patients being 22.9 years. This age is lower than the one observed in AFS developing from a pre‐existent benign lesion (mean 33 years). Although regional and distant metastases are very infrequent, AFS is a locally aggressive lesion, with 23 (37%) of the reported cases having at least one recurrence; 12 patients (19.3%) died of the disease. Wide surgical excision with long‐term follow‐up remains the treatment of choice for this neoplasm.