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Expression of hMSH2 and hMLH1 proteins of the human DNA mismatch repair system in ameloblastoma
Author(s) -
Castrilli Graziella,
Piantelli Mauro,
Artese Luciano,
Perfetti Giorgio,
Rubini Corrado,
Fioroni Massimiliano,
Ranelletti Franco O.,
Piattelli Adriano
Publication year - 2001
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1034/j.1600-0714.2001.300508.x
Subject(s) - dna mismatch repair , dna repair , biology , immunohistochemistry , ameloblastoma , dna damage , mutation , dna , gene , cancer research , microbiology and biotechnology , genetics , anatomy , immunology , maxilla
Abstract: The human DNA mismatch repair (hMMR) system plays an important role in reducing mutation and maintaining genomic stability. The MMR system in human cells is composed of at least six genes ( hMSH2, hMLH1, hMSH3, hPMS1, hPMS2 and GTBP/hMSH6 ). In particular, hMSH2 and hMLH1 are expressed in human cells that are undergoing rapid renewal; their reduced expresion has been reported in several tumors. We examined the protein expression pattern of hMSH2 and hMLH1 by immunohistochemistry in 25 ameloblastomas. All ameloblastomas expressed hMSH2 and hMLH1 proteins in the outer layer of epithelial cells. The localization of the staining was exclusively nuclear. These data suggest that the development and progression of these tumors do not depend on a defect in the hMMR system.