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Serum antioxidant micronutrient levels in oral lichen planus
Author(s) -
Nagao Toru,
Warnakulasuriya Saman,
Ikeda Noriaki,
Fukano Hideo,
Yamamoto Shigeo,
Yano Masatoshi,
Miyazaki Hideo,
Ito Yoshinori
Publication year - 2001
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1034/j.1600-0714.2001.300502.x
Subject(s) - micronutrient , oral lichen planus , antioxidant , medicine , lichen , dermatology , traditional medicine , chemistry , pathology , biology , biochemistry , botany
The aim of this study was to elucidate any association between oral lichen planus (OLP) and serum antioxidant micronutrients by a population‐based case‐control study. A total of 9536 subjects were examined, and 62 (58 reticular, 4 atrophic and erosive) diagnosed with OLP at referral facilities were compared with four controls per case ( n =248) selected among disease‐free subjects matched for age and sex. Serum levels of micronutrients (retinol, α‐tocopherol, zeaxanthin/lutein and cryptoxanthin, lycopene, α‐carotene and β‐carotene) were estimated by the high performence liquid chromatography (HPLC) method. Among cases, mean serum retinol level (2.820±0.849 μmol/l) was significantly higher compared with that of controls (2.562±0.735 μmol/l) ( P <0.05). No significant differences were noted in carotenoid levels examined in this study, except for a lower level of lycopene found in atrophic/erosive OLP cases. The results of this study suggest that low serum retinol or carotenoid levels are not risk factors for occurrence of lichen planus, and any specific benefits of antioxidant micronutrients cannot be claimed for this inflammatory disorder.