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Sialochemical markers of salivary gland involvement with Sjögren’s syndrome secondary to rheumatoid arthritis and primary biliary cirrhosis
Author(s) -
Carpenter Guy H.,
Proctor Gordon B.,
Pankhurst Caroline L.,
O'Donohue John,
Scott David,
Hunnable Mark P.
Publication year - 2000
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1034/j.1600-0714.2000.290906.x
Subject(s) - primary biliary cirrhosis , lactoferrin , rheumatoid arthritis , medicine , beta 2 microglobulin , cystatin , gastroenterology , autoimmune disease , pathology , immunology , cystatin c , biology , disease , genetics , renal function
Sjögren’s syndrome is an autoimmune condition affecting the lacrimal and salivary glands and can be associated with rheumatoid arthritis and primary biliary cirrhosis. Parotid salivas collected from patients and normal controls were analysed for lactoferrin, IgA and beta 2 ‐microglobulin (measured by ELISA), and cystatin (measured by a enzyme inhibition assay). Output data provided less variable means, whilst expressing results as a proportion of the total protein provided greater specificity as markers for Sjögren’s syndrome. Levels of specificity for IgA, lactoferrin and beta 2 ‐microglobulin were all high (100, 95 and 100%, respectively). Sensitivity levels of these markers (but not cystatin) tended to be similar for Sjögren’s syndrome secondary to primary biliary cirrhosis (IgA, 25%; lactoferrin, 63%; and beta 2 ‐microglobulin, 50%), compared to Sjögren’s syndrome secondary to connective tissue diseases such as rheumatoid arthritis (IgA, 50%; lactoferrin, 86%; and beta 2 ‐microglobulin; 38%).