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Chronic immune stimulation accelerates SIV‐induced disease progression
Author(s) -
Villinger François,
Rowe Thomas,
Parekh Bharat S.,
Green Timothy A.,
Mayne Ann E.,
Grimm Bennett,
McClure Harold M.,
Lackner Andrew A.,
Dailey Peter J.,
Ansari Aftab A.,
Folks Thomas M.
Publication year - 2001
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1034/j.1600-0684.2001.d01-57.x
Subject(s) - keyhole limpet hemocyanin , immune system , peripheral blood mononuclear cell , seroconversion , immunology , toxoid , tetanus , antibody , simian immunodeficiency virus , biology , virology , medicine , vaccination , immunization , biochemistry , in vitro
The contribution of chronic immune stimulation on the progression of lentivirus‐induced disease was evaluated in the SIVmac251 macaque model of AIDS. Following SIV inoculation, seroconversion and control of the acute viral replication phase, repeated immune stimulations with tetanus toxoid (TT), keyhole limpet hemocyanin (KLH) and allogeneic peripheral blood mononuclear cells (PBMC) were initiated in four monkeys. These animals showed a significant shortening of survival when compared with eight non‐immune‐stimulated control animals inoculated with the same route, dose and stock of SIVmac251 (median survival 9.5 months versus 17 months, P =0.010). In addition, when the comparison was extended to another 22 control animals of different origin but inoculated by the same route with similar doses and stocks of SIVmac251, the difference in survival was still significant (9.5 versus 18 months, P =0.003). This accelerated progression of symptomatic disease was not accompanied with significant increases in plasma viral loads, but suboptimal antibody responses to the immunizing antigens were noted, correlating with the length of survival. These findings may have implications for HIV‐infected humans suffering from chronic infectious diseases.