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Comparison of early plasma RNA loads in different macaque species and the impact of different routes of exposure on SIV/SHIV infection
Author(s) -
Ten Haaft Peter,
Almond Neil,
Biberfeld Gunnel,
Cafaro Aurelio,
Cranage Martin,
Ensoli Barbara,
Hunsmann Gerhard,
Polyanskaya Natasha,
StahlHennig Christiane,
Thortensson Rigmor,
Titti Fausto,
Heeney Jonathan
Publication year - 2001
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1034/j.1600-0684.2001.d01-54.x
Subject(s) - simian immunodeficiency virus , macaque , virology , rhesus macaque , biology , virus , simian , viral load , rna , lentivirus , significant difference , immunology , viral disease , medicine , gene , paleontology , biochemistry
Various simian immunodeficiency virus (SIV) sm/mac and simian/human immunodeficiency virus (SHIV) strains are used in different macaque species to study AIDS pathogenesis, as well as to evaluate candidate vaccine and anti‐retroviral drugs efficacy. In this study we investigated the effect of route of infection, species of macaques and nature of virus stock on early plasma viral RNA load. We monitored the plasma RNA concentrations of 63 rhesus ( Macaca mulatta ) and cynomolgus macaques ( Macaca fascicularis ) infected with well‐characterised virus stocks administered either by oral, rectal, vaginal or intravenous (i.v.) routes. In SIV mac ‐infected macaques, no significant difference in plasma RNA loads was observed between the rectal, oral and i.v. routes of infection. Cynomolgus macaques developed lower steady state SIV plasma RNA concentrations compared with rhesus macaques and no significant difference was observed between rectal and i.v. routes of infection. In SHIV 89.6p ‐infected macaques, no difference between species or between route of infection was observed with this particular chimeric virus.