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Molecular cloning of three nonhuman primate follicle stimulating hormone β‐subunit cDNAs
Author(s) -
Wolfgang M.J.,
Grendell R.L.,
Golos T.G.
Publication year - 2001
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1034/j.1600-0684.2001.300602.x
Subject(s) - marmoset , callithrix , primate , biology , complementary dna , molecular cloning , cloning (programming) , protein subunit , microbiology and biotechnology , follicle stimulating hormone , hormone , genetics , gene , endocrinology , luteinizing hormone , neuroscience , paleontology , computer science , programming language
The follicle stimulating hormone (FSH) β‐subunit cDNAs were cloned and sequenced for an old world primate, the rhesus monkey ( Macaca mulatta ), and two New World primates, the common marmoset ( Callithrix jacchus ) and pygmy marmoset ( Cebuella pygmaea ). The cDNA and predicted amino acid sequences of the rhesus monkey FSH β‐subunit were related most closely to the human FSH β ‐subunit (>96% identity). The common and pygmy marmosets have identical FSH β ‐subunit cDNAs, whereas the marmoset FSH β ‐subunit diverges from the rhesus and human molecules with less than 93% identity. These results have significance for the implementation of assisted reproductive technologies in the nonhuman primate as well as the evolution of genes encoding reproductive hormones.