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Subcutaneous hemangiosarcomas in a rhesus macaque ( Macaca mulatta )
Author(s) -
Myers Jr. Daniel D.,
Dysko Robert C.,
Chrisp Clarence E.,
Decoster John L.
Publication year - 2001
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1034/j.1600-0684.2001.300209.x
Subject(s) - hemangiosarcoma , histopathology , pathology , immunohistochemistry , rhesus macaque , biology , exploratory laparotomy , h&e stain , anatomy , angiosarcoma , medicine , immunology
Hemangiosarcoma is a malignant tumor of vascular endothelial cell origin. The occurrence of hemangiosarcoma in nonhuman primates has been rarely documented. An adult male rhesus monkey was reported having a firm subcutaneous swelling, approximately 4.5 cm in diameter, on the ventral midline of the abdomen. Fine‐needle aspiration, microbial culture, biopsy, radiographs, exploratory laparotomy, histopathology, immunohistochemistry, hematology, and serology were performed. A second subcutaneous mass approximately 4.5×4.0×2.7 cm developed on the ventral midline several weeks later. A fine‐needle aspirate of the first mass consisted of numerous erythrocytes with few polymorphonuclear cells and lymphocytes. Histopathology showed foci of spindle‐shaped cells surrounding the vascular spaces. Many spindle‐shaped cells had prominent nucleoli, and mitotic figures could occasionally be seen. Immunohistochemical staining of the masses for Factor VIII‐related antigen, an endothelial cell and tumor marker, yielded positive results. Both masses were consistent with hemangiosarcoma.