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A spontaneously occurring mammary gland ductal carcinoma in situ in a rhesus macaque ( Macaca mulatta ) and a review of spontaneous mammary gland tumors in rhesus monkeys
Author(s) -
Cohen Michele,
Saidla John E.,
Schlafer Donald H.
Publication year - 2001
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1034/j.1600-0684.2001.300208.x
Subject(s) - mammary gland , rhesus macaque , macaque , biology , primate , pathology , mouse mammary tumor virus , ductal carcinoma , retrovirus , mammary tumor , virus , cancer , medicine , breast cancer , immunology , neuroscience , genetics
A spontaneous mammary gland ductal carcinoma in situ was diagnosed in a 6–8‐year‐old female rhesus macaque ( Macaca mulatta) . To our knowledge, this is only the tenth case of spontaneous mammary gland tumors to be reported in rhesus monkeys. Despite the paucity of case reports, several theories exist to explain the occurrence of mammary tumors. The Mason–Pfizer monkey virus, a type D retrovirus similar to the virus that causes simian acquired immunodeficiency syndrome, has been implicated as a possible etiologic agent. Because this virus has been isolated from normal primate mammary tissue, it is unlikely to be the sole etiologic agent. Other theories include the tumorogenic effects that androgens, growth hormones, irradiation, and aging have on the mammary gland.