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Seasonal changes of humoral and cellular immune responses to Japanese cedar ( Cryptomeria japonica ) pollen allergens in Japanese monkeys ( Macaca fuscata ) with pollinosis
Author(s) -
Sakaguchi Masahiro,
Yamada Tomoko,
Hirahara Kazuki,
Shiraishi Akio,
Saito Saburo,
Miyazawa Hiroshi,
Taniguchi Yoshifumi,
Inouye Sakae,
Nigi Hideo
Publication year - 2001
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1034/j.1600-0684.2001.300207.x
Subject(s) - cryptomeria , pollen , biology , japonica , immune system , immunology , immunoglobulin e , antibody , botany
The natural occurrence of Japanese cedar [ Cryptomeria japonica (CJ)] pollinosis has been reported in Japanese monkeys ( Macaca fuscata ). The present study was designed to investigate seasonal changes in immunological reactions to CJ pollen allergens in monkeys with CJ pollinosis. Blood samples were collected from six monkeys with CJ pollinosis before and after CJ pollen season. Seasonal changes in specific IgE and IgG to major allergens (Cry j 1 and Cry j 2) were observed before and after CJ pollen season. The humoral responses decreased significantly before CJ pollen and increased after CJ pollen season. Similar seasonal changes in peripheral blood mononuclear cells proliferative responses to CJ allergens were observed before and after CJ pollen season. These humoral and cellular immune responses might serve as a biomarker for assessing new immunotherapies for monkeys with pollinosis.