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Expression of β‐defensin‐1 in chimpanzee ( Pan troglodytes ) airways
Author(s) -
Duits Louise A.,
Langermans Jan A.M.,
Paltansing Sunita,
Van Der Straaten Tahar,
Vervenne Richard A.W.,
Frost Patrice A.,
Hiemstra Pieter S.,
Thomas Alan W.,
Nibbering Peter H.
Publication year - 2000
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1034/j.1600-0684.2000.290502.x
Subject(s) - defensin , biology , complementary dna , peptide sequence , messenger rna , in situ hybridization , microbiology and biotechnology , gene , immunology , genetics
In human airways, β‐defensins function in the elimination of various pathogens. They have been identified in a wide range of species. Here we report the identification and expression of chimpanzee β‐defensin‐1 (cBD1), which is a homolog of human β‐defensin‐1, in chimpanzee airways and skin. The cBD1 cDNA sequence differs by only one synonymous nucleotide substitution compared to the human cDNA sequence. In situ hybridization revealed that in lung tissue beside alveolar macrophages also airway epithelial cells, endothelial cells and type II pneumocytes express cBD1 mRNA. In skin, cBD1 mRNA was expressed in keratinocytes and endothelial cells. Together, these results show similarity in structure and expression pattern and perhaps in function.