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Total numbers of lymphocyte subsets in different lymph node regions of uninfected and SIV‐infected macaques
Author(s) -
Halbach Astrid,
Nierwetberg* Dagmar,
Müller Justus G.,
Sauer Ursula,
Kerkau Thomas,
Stolte Nicole,
Hofmann Petra,
Czub Stephanie,
Ter Meulen Volker,
Sopper Sieghart
Publication year - 2000
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1034/j.1600-0684.2000.290308.x
Subject(s) - simian immunodeficiency virus , biology , lymph node , immunology , lymphocyte , virology , lymphocyte subsets , virus , lymphatic system , lymph , immunodeficiency , human immunodeficiency virus (hiv) , immune system , t cell , pathology , medicine
Human immunodeficiency virus (HIV) infection leads to a decline of CD4 + T‐cells in blood. Because blood represents only a small proportion of the total lymphocyte pool, it is important to investigate other lymphoid organs. So far, only relative proportions of lymphocyte subsets in single peripheral lymph node (LN) regions of HIV‐infected patients and simian immunodeficiency virus (SIV)‐infected macaques have been documented. We have therefore quantified the absolute numbers of lymphocyte subsets in blood and six different LN regions of 10 uninfected and 26 SIV‐infected macaques. In addition, we have determined the expression of markers of activation and differentiation. Already, in uninfected monkeys, there were significant differences in the cellular composition of different LN regions. Infection with SIV resulted in drastic changes in the proportion as well as absolute numbers of different lymphocyte subsets. Moreover, the relative contribution of the single LN regions to the total lymphocyte pool was also altered.