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Down‐regulation of macaque ΓΔ+ T cells in lymphoid compartments after rectal infection with SIVsmmPBj14
Author(s) -
Chen Zheng W.,
Shen Yun,
Davis Ian C.,
Shen Ling,
Letvin Norman L.,
Fultz Patricia N.
Publication year - 2000
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1034/j.1600-0684.2000.290307.x
Subject(s) - macaque , biology , simian immunodeficiency virus , rhesus macaque , t cell , population , immunology , lymphatic system , virology , virus , immunodeficiency , immune system , medicine , paleontology , environmental health
The dynamics of T cells expressing the ΓΔ T‐cell receptor in mucosae and other compartments during the course of human immunodeficiency virus (HIV)‐1 infection are poorly understood. To examine the impact of an acquired immunodeficiency syndrome virus on the ΓΔ+ T‐cell population, rectal inoculation of macaques with simian immunodeficiency virus (SIV)‐PBj14 was used as a model. After rectal inoculation, five macaques were sacrificed on days 4, 5, or 7 and then assessed for changes in the ΓΔ T‐cell receptor repertoire in different lymphoid compartments. There was decreased representation of ΓΔ+ T cells in the intestinal mucosae, blood, and spleens. Overall, the reduced number of total ΓΔ+ T cells was consistent with decreases in the VΓ or VΔ T‐cell sub‐populations. Nevertheless, there was no consistent deletion or expansion of a selected VΓ+ or VΔ+ cell sub‐population. These results demonstrate that SIV‐PBj14 replication and dissemination after mucosal inoculation resulted in a decline of detectable ΓΔ+ T cells, suggesting that macaque ΓΔ+ T cells are susceptible to down‐regulation or destruction during acute SIV‐PBj14 infection.