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Dietary content may prevent secondary hyperparathyroidism in female rhesus monkeys ( Macaca mulatta )
Author(s) -
Bruner Julia E.,
Davidowitz Bradley I.,
Haffa Arlene M.,
Binkley Neil
Publication year - 2000
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1034/j.1600-0684.2000.290103.x
Subject(s) - endocrinology , medicine , parathyroid hormone , osteocalcin , secondary hyperparathyroidism , vitamin d and neurology , alkaline phosphatase , rhesus macaque , vitamin d deficiency , hyperparathyroidism , bone remodeling , calcium , chemistry , enzyme , biochemistry , immunology
Macaque laboratory chows provide relatively more calcium (Ca) and vitamin D (D) than human diets; this may influence skeletal aging. To evaluate this possibility, parameters of skeletal relevance in premenopausal and naturally postmenopausal rhesus monkeys were measured in a cross‐sectional study. Serum osteocalcin (Oc) was elevated in the postmenopausal group ( P <0.01), but levels of parathyroid hormone (PTH) and 25‐hydroxyvitamin D (25OHD) were not different. Subsequently, in premenopausal animals, dietary Ca and/or D intake was reduced to optimal human levels for 8 weeks prior to the evaluation of the skeletal parameters. Serum 25OHD concentration was reduced ( P <0.01) and a trend ( P =0.10) towards increased PTH was observed in both low D groups. In addition, serum alkaline phosphatase (ALP) levels were increased in the low Ca group ( P <0.01). In conclusion, skeletal turnover, as measured by serum Oc, was increased in naturally postmenopausal rhesus monkeys in the absence of hyperparathyroidism. Dietary D reduction causes a decline in serum 25OHD and an upward trend in PTH.