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The role of Tec family kinases in T cell development and function
Author(s) -
Lucas Julie A.,
Miller Andrew T.,
Atherly Luana O.,
Berg Leslie J.
Publication year - 2003
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2003.00029.x
Subject(s) - nfat , microbiology and biotechnology , biology , kinase , t cell receptor , transcription factor , signal transduction , tec , cellular differentiation , phosphorylation , t cell , immunology , genetics , immune system , gene , ionosphere , physics , astronomy
Summary: Three members of the Tec family kinases, Itk, Rlk and Tec, have been implicated in signaling downstream of the T cell receptor (TCR). The activity of these kinases in T cells has been shown to be important for the full activation of phospholipase C‐γ1 (PLC‐γ1). Disruption of Tec family signaling in Itk –/– and Rlk –/– Itk –/– mice has multiple effects on T cell development, cytokine production and T‐helper cell differentiation. Furthermore, mice possessing mutations in signaling molecules upstream of PLC‐γ1, such as Src homology 2 (SH2) domain‐containing phosphoprotein of 76 kDa (SLP‐76), linker for activation of T cells (LAT) and Vav1, or in members of the nuclear factor for activated T cells (NFAT) family of transcription factors, which are downstream of PLC‐γ1, have been found to have similar phenotypes to Tec family‐deficient mice, emphasizing the importance of this pathway in regulating T cell activation, differentiation and homeostasis.