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The TCR ADAPts to integrin‐mediated cell adhesion
Author(s) -
Peterson Erik J.
Publication year - 2003
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2003.00026.x
Subject(s) - microbiology and biotechnology , integrin , biology , t cell receptor , cell adhesion molecule , cell adhesion , signal transduction , actin cytoskeleton , cytoskeleton , effector , signal transducing adaptor protein , t cell , receptor , cell , immunology , immune system , biochemistry
Summary: Adapter proteins regulate leukocyte signal transduction through recruitment of effector molecules to multiprotein complexes. Recent studies in Adhesion and Degranulation promoting Adapter Protein (ADAP)‐deficient mice have established that the cytoplasmic phosphoprotein ADAP is required for optimal, mature T‐cell proliferation. Furthermore, ADAP plays a key role in T‐cell antigen receptor (TCR)‐mediated ‘inside out’ signaling leading to integrin activation and to enhanced cellular adhesion to integrin ligands. ADAP associates physically with molecules known to play roles in the regulation of TCR‐stimulated actin polymerization. These associations support the hypothesis that ADAP functions in actin cytoskeletal reorganization leading to cellular adhesion and activation.