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Role of Shc in T‐cell development and function
Author(s) -
Zhang Li,
Lorenz Ulrike,
Ravichandran Kodi S.
Publication year - 2003
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2003.00025.x
Subject(s) - jurkat cells , t cell receptor , microbiology and biotechnology , signal transducing adaptor protein , biology , signal transduction , t cell , mapk/erk pathway , immunology , immune system
Summary: Shc is a prototype adapter protein that is expressed from the earliest stages of T‐cell development. Shc becomes rapidly tyrosine phosphorylated after T‐cell receptor (TCR) engagement. Expression of dominant negative forms of Shc in T‐cell lines had also suggested a role for this adapter downstream of the TCR. However, until recently, the relative significance of Shc compared to several other adapters in T cells was unclear. Mice lacking Shc expression specifically in the T‐cell lineage together with inducible expression of dominant negative Shc in transgenic mice have revealed an essential and nonredundant role for Shc in thymic T‐cell development. Functional defects in a Jurkat T‐cell line lacking Shc expression also suggest a role for Shc in mature T‐cell functions. While the requirement of Shc in T‐cell signaling is now established, precisely what signaling pathways downstream of Shc make this adapter unique are less clear. Although the Shc‐mediated activation of the extracellular signal regulated kinase (Erk)/mitogen‐activated protein kinase (MAPK) pathway could be one component, Shc likely signals to other pathways in T cells that are not yet discovered. A better molecular understanding of Shc function in the future could provide insights into how multiple adapters coordinate the various outcomes downstream of the TCR.