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Kinetic perspectives of T cell antigen receptor signaling
Author(s) -
Iwashima Makio
Publication year - 2003
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2003.00024.x
Subject(s) - t cell receptor , t cell , microbiology and biotechnology , signal transduction , biology , receptor , interleukin 2 , mechanism (biology) , co stimulation , cell , antigen , immunology , immune system , cd28 , genetics , physics , quantum mechanics
Summary: T‐cell activation consists of multiple layers of signaling events. Interleukin‐2 production is of interest for many, since its expression determines a critical difference between partial and full T‐cell activation. To achieve full activation of T cells, it is necessary for the T‐cell antigen receptor (TCR) to be engaged for an extended period of time. However, why extended stimulation is required for full T‐cell activation is not understood at the molecular level. In this review, orchestrated events of TCR signal transduction will be analyzed in a kinetic manner and connected toward the understanding of the mechanism of T‐cell activation. Based on recent results, a model of the mechanism that dictates the threshold between partial and full T‐cell activation is proposed.