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An evolutionary and structural perspective on T cell antigen receptor function
Author(s) -
Malissen Bernard
Publication year - 2003
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2003.00016.x
Subject(s) - t cell receptor , immunoreceptor tyrosine based activation motif , receptor , biology , computational biology , signal transduction , function (biology) , antigen , microbiology and biotechnology , genetics , t cell , immune system
Summary: After a brief overview of the themes and variations that occur in the family of receptors containing immunoreceptor tyrosine‐based activation motifs (ITAMs), and of recent structural data on the ligand‐binding subunits of these receptors, we use these data to revisit how information on the state and quality of occupancy of the binding site of the T cell antigen receptor (TCR) is conveyed to the proximal components of the TCR transduction cassette.