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Membrane–cytoskeleton interactions during the formation of the immunological synapse and subsequent T‐cell activation
Author(s) -
Das Vincent,
Nal Béatrice,
Roumier Anne,
MeasYedid Vannary,
Zimmer Christophe,
OlivoMarin JeanChristophe,
Roux Pascal,
Ferrier Pierre,
DautryVarsat Alice,
Alcover Andrés
Publication year - 2002
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2002.18911.x
Subject(s) - immunological synapse , cytoskeleton , microbiology and biotechnology , ezrin , biology , intracellular , synapse , cell membrane , cell , t cell , t cell receptor , immunology , neuroscience , biochemistry , immune system
Summary: Upon antigen recognition, T cells undergo substantial membrane and cytoskeletal rearrangements that lead to the formation of the immunological synapse and are necessary for subsequent T‐cell activation. However, little is known about how membrane and cytoskeletal molecules interact during these processes. Here we discuss the involvement of the membrane‐microfilament linker ezrin. We propose that ezrin is a component of the cytoskeleton‐mediated architecture of the immunological synapse that plays a role in T‐cell receptor clustering, protein kinase C θ translocation and intracellular signaling.