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Genetic analysis of integrin activation in T lymphocytes
Author(s) -
Kellermann SiridAimée,
Dell Cheryl L.,
Hunt Stephen W.,
Shimizu Yoji
Publication year - 2002
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2002.18615.x
Subject(s) - t cell receptor , biology , cd3 , immune system , microbiology and biotechnology , integrin , t cell , signal transduction , immunology , cytokine , receptor , genetics , cd8
Summary: Among the myriad receptors expressed by T cells, the sine qua non is the CD3/T cell receptor (CD3/TCR) complex, because it is uniquely capable of translating the presence of a specific antigen into intracellular signals necessary to trigger an immune response against a pathogen or tumor. Much work over the past 2 decades has attempted to define the signaling pathways leading from the CD3/TCR complex that culminate ultimately in the functions necessary for effective T cell immune responses, such as cytokine production. Here, we summarize recent advances in our understanding of the mechanisms by which the CD3/TCR complex controls integrin‐mediated T cell adhesion, and discuss new information that suggests that there may be unexpected facets to this pathway that distinguish it from those previously defined.