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The thymus and negative selection
Author(s) -
Sprent Jonathan,
Kishimoto Hidehiro
Publication year - 2002
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2002.18512.x
Subject(s) - negative selection , biology , central tolerance , self tolerance , clonal deletion , antigen , immunology , population , peripheral tolerance , selection (genetic algorithm) , positive selection , immune tolerance , t cell , t cell receptor , genetics , immune system , gene , medicine , environmental health , genome , artificial intelligence , computer science
Summary: Maintenance of tolerance to self antigens is presumed to reflect a combination of central and peripheral tolerance. For T cells, central tolerance occurs during early T cell development in the thymus and causes cells with strong reactivity to self antigens to be destroyed in situ (negative selection). Here, we summarize evidence that negative selection can occur in the thymic medulla and affects a population of semimature HSA + T cells. The influence of costimulatory molecules, Fas and cytokines on negative selection is discussed.