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Genomic and funtional aspects of the rat MHC, the RT1 complex
Author(s) -
Dressel Ralf,
Walter Lutz,
Günther Eberhard
Publication year - 2001
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2001.1840108.x
Subject(s) - major histocompatibility complex , biology , contig , gene , cytotoxic t cell , genetics , immune system , heat shock protein , hsp70 , cd8 , gene expression profiling , heat shock , haplotype , gene expression , microbiology and biotechnology , genotype , genome , in vitro
Summary: The major histocompatibility complex (MHC) plays a central role in controlling immune responsiveness, susceptibility to certain diseases and histo‐incompatibility. A physical map of the complete rat MHC, the RT1 complex, is presented based on a PAC clonal contig (RT1 n haplotype). Expression profiling of various tissues of different inbred strains has been carried out for genes of the RT1 ‐C/E/M region, and different types of variability of expression are shown. As an example of single gene analysis, the RT1‐linked heat shock‐inducible heat shock genes Hsp70 ‐1 and Hsp70 ‐2 have been studied. It is demonstrated that their gene products are able to increase lysability of target cells by cytotoxic T lymphocytes.