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Thymic development and repertoire selection: the rat perspective
Author(s) -
Hünig Thomas,
TorresNagel Nora,
Mehling Beatrix,
Park HyunJung,
Herrmann Thomas
Publication year - 2001
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1034/j.1600-065x.2001.1840102.x
Subject(s) - biology , repertoire , thymocyte , cd8 , lineage (genetic) , germline , t cell receptor , major histocompatibility complex , negative selection , immunology , t cell , somatic cell , compartment (ship) , microbiology and biotechnology , receptor , genetics , immune system , genome , gene , oceanography , physics , acoustics , geology
Summary: This review summarizes our current knowledge of T‐cell maturation and repertoire selection in the rat thymus. Some unique features of early thymocyte development and of CD4/CD8 lineage decision are described. A detailed analysis of lineage progression through the CD4, CD8 “double positive” compartment and T‐cell receptor‐induced CD8 T‐cell maturation in cell culture is provided. A second emphasis is placed on interactions between germline‐encoded T‐cell receptor elements with MHC molecules in thymic repertoire selection and alloreactivity